Clinical Neuroimmunology

Clinical
Neuroimmunology
edited by
F. CLIFFORD ROSE

Contributors ix
Foreword xv
Preface xvii

PART I. GENERAL ASPECTS

1 General Introduction 3
D. GERAINT JAMES
2 Some Aspects of Immune Reactions of the Brain 12
H. LINK
3 Brain Glycolipids in Cell- Surface Antigens 29
S. LEIBOWITZ & N. A. GREGSON
4 The Relevance of HLA Antigens in some Neurological Diseases 42
J. A. SACHS
5 Immunodeficiency and CNS Disease 53
L. P. WEINER & S. A. STOHLMAN
6 Antineuronal Antibodies in Diseases Affecting the Bsal Ganglia, 90
Particularly Sydenham's and Huntington's Chorea
G. HUSBY , R. C. WILLIAMS , R. M. BERSIN & M. K. LEWIS
7 Retinal Vasculitis : Ophthalmological Aspects of Neuroimmu - 106
nological Disease
M. D. SANDERS

PART II. MUSCLE DISEASE

8 Experiment Autoimmuune Myasthenia Gravis 115
A . VINCENT
9 Anti-acetylcholine Receptor Antibody in Myasthenia Gravis 128 J. NEWSOM – DAVIS
10 Role of Thymus in Myasthenia Gravis 137
G. K. SCADDING
11 Current Progress in the Study of Allergic Polymyositis in the 146
Guinea-pig and Man
P. D. SMITH, R. C. BUTLER, T. A. PARTRIDGE & J. C. SLOPER




PART III. PERIPHERAL NEUROPATHIES

12 Experimental Allergic Neuritis 155
M. B. PEPYS
13 Allergic Neuritis in Man and Animals 165
P. K. THOMAS
14 Acute Inflammatory Polyneuropathy 170
R. A. C. HUGHES
15 A etiology of Bell's palsy 185
R. CAPILDEO
16 Peripheral Neuropathy in Rheumatoid Arthritis 201
J. T. SCOTT
17 Neuritis in Leprosy : A Study of Borderline Leprosy Reaction 208
R. ST. C. BARNETSON

PART IV. MOTOR NEURONE DISEASE

18 Immunological Considerations in Amyotrophic Lateral Sclerosis 227
( A L S )
J. ANTEL , M. E. MEDOF , P. RICHMAN & B. G. W. ARNASON
19 The Riddle of Positive Immune System Findings in Amyotrophic 245
Lateral Sclerosis
F, H. NORRIS , Jr .
20 Cell-mediated Immunity in Motor Neurone Disease and 259
Poliomyelitis
P. O. BEHAN

PART V. MULTIPLESCLEROSIS

21 The Paradox of Immunity and Infection in Multiple Sclerosis 275
D. C. DUMONDE
22 Experimental Allergic Encephalomyelitis as a Working Model 299
for Multiple Sclerosis ? A Critical Evaluation
E. A. CASPARY
23 Relationship of Acute Disseminated Encephalomyelitis and 305
Acute Transverse Myelopathy to Experimental Allergic
Encephalomyelitis
O. ABRAMSKY
24 Optic Neuritis and Multiple Sclerosis : An Immunological 312
Comparison
G. D. PERKIN
25 Lymphocyte Function and Activity of Disease in Multiple 329
Sclerosis
S. C. KNIGHT
26 Oligoclonal Gammaglobulin in Relation to Clinical Classification 338
in Multiple Sclerosis
E. J. THOMPSON
27 Immunological Studies of Isolated Oligodendrocytes in Relation 344
to Multiple Sclerosis
O. ABRAMSKY
28 Significance of Virus Antibodies in Multiple Sclerosis 354
M. HAIRE